High Specialization
Our focus is the research, development, and manufacturing of drugs for the treatment of complex conditions. Our mission is to promote the improvement in the quality of life through state-of-the-art therapeutic solutions, guaranteeing the highest safety and efficiency standards at an affordable price.
The first biogeneric in Latin America
The first Etanercept biosimilar in Latin America, developed at the biotechnology development center in Argentina (Gema Biotech).
Its development involves all processes, from the selection of clones to the production of purified proteins, and the formulation of finished products. This methodology allows us to offer our customers a high added value through the complete integration of processes, thus guaranteeing the origin and consistent quality of our products.
Pre-clinical and clinical studies to ensure biosimilarity were developed according to the guidelines for biosimilar drugs of the most demanding regulatory agencies, such as the EMA and FDA.
Exadia (Etanercept) is a tumor necrosis factor (TNF) inhibitor. It works by blocking the action of TNF, a substance that causes inflammation and, consequently, damage at joint level.
It is marketed in pre-filled 25 mg and 50 mg syringes for one-month treatments. It is prescribed for the reduction and improvement of: rheumatoid arthritis and active rheumatoid arthritis with psoriatic arthritis, alone or combined with other drugs; polyarticular juvenile idiopathic arthritis; active rheumatoid arthritis with psoriatic arthritis combined with other drugs in patients refractory to other drugs; active ankylosing spondylitis; moderate or severe chronic plaque psoriasis in patients over 18 years old who are intolerant or other systemic treatments, such as cyclosporine or methotrexate, are not advised.
High-tech, safe, effective and accessible drugs
| Oncology | Hemato-oncology | Autoimmunity | Transplants |
Biotechnology
Iclos Biotechnology has a vertical integration model that covers all stages of production, from cell engineering and culture to the production of active ingredients and the manufacture of finished products.
Chemical Synthesis
Our chemical synthesis drugs are manufactured at the Iclos pharmaceutical plant in Uruguay, engaged in the production of segregated solids, immunosuppressants, antiproliferative agents and oncological products. The plant was designed considering product protection as well as care for the environment and operators.
State-of-the-Art Infrastructure
Iclos has three drug development centers. The center for the development of biotechnological products is located in Argentina and is engaged in expression and fermentation processes, both in mammalian and bacterial cells. The area engaged in the development of segregated solids, oncological products and immunosuppressants is located in Uruguay, as is the area of non-segregated product development. These are reference centers at regional level.
Iclos plants have state-of-the-art technological equipment and strict environmental controls. Our aim is to have a positive impact on the communities and countries in which we operate. This involves defending and encouraging the implementation of environmentally friendly policies at our different production stages.
We Build Knowledge
Our Research and Development Department is in close contact with institutions creating knowledge and role models from the scientific community. Research processes carried out for the development of biosimilar products involve different stakeholders contributing their strengths and abilities with the objective of obtaining high-quality drugs for our specialization areas.