{"id":86080,"date":"2021-04-20T13:32:51","date_gmt":"2021-04-20T16:32:51","guid":{"rendered":"https:\/\/iclos.global\/eng\/?post_type=product&p=86080"},"modified":"2021-04-20T13:42:30","modified_gmt":"2021-04-20T16:42:30","slug":"botemib","status":"publish","type":"product","link":"https:\/\/iclos.global\/eng\/producto\/botemib\/","title":{"rendered":"Botemib"},"content":{"rendered":"

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Principio activo: Bortezomib
\nPresentaciones: Vial Liof 1.0 mg 10 ml x1, Vial Liof 2.50 mg 10 ml x 1, Vial Liof 3.50 mg 10 ml x 1<\/h3>\n

 <\/p>\n

<\/h4>\n

Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos)<\/strong><\/p>\n

Botemib es un antineopl\u00e1sico, de acci\u00f3n citot\u00f3xica, que destruye las c\u00e9lulas tumorales.
\nEl Bortezomib es un inhibidor del proteosoma dise\u00f1ado espec\u00edficamente para inhibir la actividad quimotripsina del proteosoma 26S en c\u00e9lulas de mam\u00edfero provocando la detenci\u00f3n del ciclo celular y la apoptosis.[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=\u00bb0″ overlay_alpha=\u00bb50″ gutter_size=\u00bb3″ column_width_percent=\u00bb100″ shift_y=\u00bb0″ z_index=\u00bb0″ el_class=\u00bbcatalogo-item\u00bb][vc_column width=\u00bb1\/1″][vc_row_inner][vc_column_inner width=\u00bb1\/1″][vc_empty_space empty_h=\u00bb0″][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=\u00bb5\/6″][vc_column_text][\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00bb1\/6″][vc_column_text]\"\"[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Principio activo: Bortezomib
\nPresentaciones: Vial Liof 1.0 mg 10 ml x1, Vial Liof 2.50 mg 10 ml x 1, Vial Liof 3.50 mg 10 ml x 1<\/h3>\n

 <\/p>\n

<\/h4>\n

Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos)<\/strong><\/p>\n

Botemib es un antineopl\u00e1sico, de acci\u00f3n citot\u00f3xica, que destruye las c\u00e9lulas tumorales.
\nEl Bortezomib es un inhibidor del proteosoma dise\u00f1ado espec\u00edficamente para inhibir la actividad quimotripsina del proteosoma 26S en c\u00e9lulas de mam\u00edfero provocando la detenci\u00f3n del ciclo celular y la apoptosis.<\/p>\n

Indicaciones terap\u00e9uticas<\/strong><\/p>\n

Linfoma de c\u00e9lulas del manto en pacientes adultos
\nMieloma m\u00faltiple en pacientes adultos<\/p>\n

Aprobaciones y pautas (FDA; EMA; ASCO; ESMO)<\/strong><\/p>\n

Ha sido aprobado por EMA y FDA para las indicaciones anteriormente mencionadas.<\/p>\n

Dosis y plan terap\u00e9utico<\/strong><\/p>\n

La dosis y el plan terap\u00e9utico depender\u00e1 de la indicaci\u00f3n.
\nDosis recomendad: 1,3 mg\/m2\/dosis por v\u00eda IV o SC.
\nAjustar la dosis en caso de toxicidad hematol\u00f3gica o no hematol\u00f3gica, dolor neurop\u00e1tico o neuropat\u00eda perif\u00e9rica.<\/p>\n

Por m\u00e1s informaci\u00f3n ver la ficha t\u00e9cnica del producto.<\/em><\/p>\n","protected":false},"featured_media":86081,"template":"","meta":[],"product_cat":[125],"product_tag":[],"class_list":{"0":"post-86080","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sin-categorizar","7":"pa_area-terapeutica-hemato-oncologia","8":"pa_nombre-botemib","9":"pa_principio-activo-bortezomib","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nBotemib - ICLOS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/iclos.global\/eng\/producto\/botemib\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Botemib - ICLOS\" \/>\n<meta property=\"og:description\" content=\"Principio activo: Bortezomib Presentaciones: Vial Liof 1.0 mg 10 ml x1, Vial Liof 2.50 mg 10 ml x 1, Vial Liof 3.50 mg 10 ml x 1   Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos) Botemib es un antineopl\u00e1sico, de acci\u00f3n citot\u00f3xica, que destruye las c\u00e9lulas tumorales. El Bortezomib es un inhibidor del proteosoma dise\u00f1ado espec\u00edficamente para inhibir la actividad quimotripsina del proteosoma 26S en c\u00e9lulas de mam\u00edfero provocando la detenci\u00f3n del ciclo celular y la apoptosis. Indicaciones terap\u00e9uticas Linfoma de c\u00e9lulas del manto en pacientes adultos Mieloma m\u00faltiple en pacientes adultos Aprobaciones y pautas (FDA; EMA; ASCO; ESMO) Ha sido aprobado por EMA y FDA para las indicaciones anteriormente mencionadas. Dosis y plan terap\u00e9utico La dosis y el plan terap\u00e9utico depender\u00e1 de la indicaci\u00f3n. Dosis recomendad: 1,3 mg\/m2\/dosis por v\u00eda IV o SC. Ajustar la dosis en caso de toxicidad hematol\u00f3gica o no hematol\u00f3gica, dolor neurop\u00e1tico o neuropat\u00eda perif\u00e9rica. 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