{"id":86112,"date":"2021-04-21T11:27:12","date_gmt":"2021-04-21T14:27:12","guid":{"rendered":"https:\/\/iclos.global\/eng\/?post_type=product&p=86112"},"modified":"2021-04-21T11:33:34","modified_gmt":"2021-04-21T14:33:34","slug":"usmal","status":"publish","type":"product","link":"https:\/\/iclos.global\/eng\/producto\/usmal\/","title":{"rendered":"Usmal"},"content":{"rendered":"

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Principio activo: Rituximab
\nPresentaciones: 500 mg x vial
\n100 mg x vial<\/h3>\n

 <\/p>\n

<\/h4>\n

Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos)<\/strong><\/p>\n

Rituximab es un anticuerpo monoclonal obtenido por ingenier\u00eda gen\u00e9tica que se une a la prote\u00edna CD20 presente en la superficie de la mayor\u00eda de los linfocitos pre-B, B y se expresa en m\u00e1s de 95% de los linfomas no Hodgkin de c\u00e9lulas B. La actividad antitumoral ocurre a trav\u00e9s de la citotoxicidad dependiente del complemento o de anticuerpos, y a trav\u00e9s del efecto citot\u00f3xico mediante el complejo ant\u00edgeno-anticuerpo.[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=\u00bb0″ overlay_alpha=\u00bb50″ gutter_size=\u00bb3″ column_width_percent=\u00bb100″ shift_y=\u00bb0″ z_index=\u00bb0″ el_class=\u00bbcatalogo-item\u00bb][vc_column width=\u00bb1\/1″][vc_row_inner][vc_column_inner width=\u00bb1\/1″][vc_empty_space empty_h=\u00bb0″][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=\u00bb5\/6″][vc_column_text][\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00bb1\/6″][vc_column_text]\"\"[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Principio activo: Rituximab
\nPresentaciones: 500 mg x vial
\n100 mg x vial<\/h3>\n

 <\/p>\n

<\/h4>\n

Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos)<\/strong><\/p>\n

Rituximab es un anticuerpo monoclonal obtenido por ingenier\u00eda gen\u00e9tica que se une a la prote\u00edna CD20 presente en la superficie de la mayor\u00eda de los linfocitos pre-B, B y se expresa en m\u00e1s de 95% de los linfomas no Hodgkin de c\u00e9lulas B. La actividad antitumoral ocurre a trav\u00e9s de la citotoxicidad dependiente del complemento o de anticuerpos, y a trav\u00e9s del efecto citot\u00f3xico mediante el complejo ant\u00edgeno-anticuerpo.<\/p>\n

Indicaciones terap\u00e9uticas<\/strong><\/p>\n

En pacientes adultos para:<\/p>\n

    \n
  • Linfoma no Hodgkin (LNH)<\/li>\n
  • Leucemia linfoc\u00edtica cr\u00f3nica (LLC)<\/li>\n
  • Artritis reumatoide (AR)<\/li>\n
  • Granulomatosis con poliange\u00edtis o poliange\u00edtis microsc\u00f3pica<\/li>\n<\/ul>\n

    Aprobaciones y pautas (FDA; EMA; ASCO; ESMO)<\/strong><\/p>\n

    Rituximab ha sido aprobado por EMA y FDA para las indicaciones anteriormente mencionadas.<\/p>\n

    Dosis y plan terap\u00e9utico<\/strong><\/p>\n

    La dosis y el plan terap\u00e9utico depender\u00e1 de la indicaci\u00f3n.
    \nDosis inicial recomendada: 375 mg\/m\u00b2 de superficie corporal v\u00eda IV
    \nArtritis reumatoide: 1000mg v\u00eda IV<\/p>\n

    Por m\u00e1s informaci\u00f3n ver la ficha t\u00e9cnica del producto.<\/em><\/p>\n","protected":false},"featured_media":86113,"template":"","meta":[],"product_cat":[125],"product_tag":[],"class_list":{"0":"post-86112","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sin-categorizar","7":"pa_area-terapeutica-biotecnologicos","8":"pa_area-terapeutica-hemato-oncologia","9":"pa_nombre-usmal","10":"pa_principio-activo-rituximab","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"yoast_head":"\nUsmal - ICLOS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/iclos.global\/eng\/producto\/usmal\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Usmal - ICLOS\" \/>\n<meta property=\"og:description\" content=\"Principio activo: Rituximab Presentaciones: 500 mg x vial 100 mg x vial   Mecanismo de acci\u00f3n y blancos moleculares (biol\u00f3gicos) Rituximab es un anticuerpo monoclonal obtenido por ingenier\u00eda gen\u00e9tica que se une a la prote\u00edna CD20 presente en la superficie de la mayor\u00eda de los linfocitos pre-B, B y se expresa en m\u00e1s de 95% de los linfomas no Hodgkin de c\u00e9lulas B. 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